Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia
نویسندگان
چکیده
منابع مشابه
Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia
BACKGROUND DNMT3A mutations represent one of the most frequent gene alterations detectable in acute myeloid leukemia (AML) with normal karyotype. Although various recurrent somatic mutations of DNMT3A have been described, the most common mutation is located at R882 in the methyltransferase domain of the gene. Because of their prognostic significance and high stability during disease evolution, ...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2015
ISSN: 1756-9966
DOI: 10.1186/s13046-015-0173-2